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People with Severe Gastrointestinal Disease: Those with severe gastrointestinal disorders might not be suitable for Semaglutide, as it may exacerbate these conditions
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The STEP-2 subgroup analysis showed that participants on background metformin had a combined diarrhea rate of 33.2% compared to 22.8% in those not taking metformin [5]
Since its approval for the treatment of diabetes, it has caught the attention of scientists and clinicians alike, as it was noted that patients using this drug for diabetes management also lost weight
It works by mimicking two hormones in the bodyGLP-1 and GIPthat help lower blood sugar and reduce appetite
How Your Genetics Relate to GLP-1 Pathways Baseline fasting glucose, HbA1c, HOMA-IR (insulin resistance index), lipid profile, and inflammatory markers (CRP, TNF-alpha) correlate with semaglutide efficacy and weekly loss trajectory
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